PRESENTER PROFILES

Translational Workshop: Cancer Immunology Discovery Approaches into Clinical Trials

Tuesday, December 10
2 – 3:45 p.m. CT
Stars at Night Ballroom 3-4

PRESENTER PROFILES

Translational Workshop: Cancer Immunology Discovery Approaches into Clinical Trials

Tuesday, December 10
2 – 3:45 p.m. CT
Stars at Night Ballroom 3-4

Presentation: Cancer Immunology Discovery Approaches into Clinical Trials

Emanuela Romano, MD, PhD
Medical Director, Center for Cancer Immunotherapy,
Institut Curie

What is your presentation about?
I will present how T-cell subsets and the T-cell receptor (TCR) dynamics can predict the clinical outcome to combinatorial chemo-immunotherapy in advanced triple-negative breast cancer (TNBC). We capitalized on scRNAseq, a novel and powerful technology that allows the sequencing of mRNA at the single cell level and discovered T-cell states and TCR dynamics associated with clinical outcome.

How do you hope your presentation will impact breast cancer research, care, or advocacy?
I hope that the biomarker we have defined in our study will be implemented along with others in prospective trials of combinatorial chemo-immunotherapy in advanced TNBC. I am convinced that combinations of predictive biomarkers can pinpoint the patients who may likely benefit from a given treatment to avoid unnecessary exposure to ineffective drugs.

How did you get involved in this particular area of breast cancer research, care, or advocacy?
Being interested in the direct interrogation of the breast cancer microenvironment in relation with the anti-tumor immune response, I had the opportunity to build academic trials and collaborate with colleagues that shared my same goals and passion. The work I will present is pretty much a teamwork!